What are MSC exosomes and what is their purpose in the cell?
Exosomes are microvesicles that are 40nm-100nm in size. They form after a two-step budding process that creates them inside membranous vesicles in an MVB (multivesicular body) in the cell.
These MVB’s fuse with the cell’s plasma membrane to release their cargo, the exosomes. Transmembrane proteins are conserved inside them and they are composed of lipids, proteins, mRNA, and miRNA.
The key advantages of exosomes are:
- Able to cross the blood-brain barrier
- They can travel via systemic therapy without the risk of clumping
- Deliver miRNA and mRNA
- They influence phenotype
- They are anti-inflammatory
- They are anti-fibrotic
Translational studies that employ MSC-derived exosomes demonstrate that they recapitulate the brand therapeutic effect that was previously attributed to MSC’s via the horizontal transfer of mRNA and miRNA and proteins. Therefore, exosomes provide the benefits of MSC’s without the stem cell material.
Some applications for Exosomes are:
- Aesthetics Micro-needling and hair restoration
- Autoimmune function and defenses
- Anti-inflammatory responses
- Sexual health
- Degenerative conditions
Add Exosomes to your practice or clinic today.